Clozapine is an atypical antipsychotic medication primarily prescribed for treatment-resistant schizophrenia, a condition where symptoms persist despite the use of other antipsychotic drugs. It is particularly effective in reducing hallucinations, delusions, and disorganized thinking in patients who have not responded to conventional treatments. Unlike typical antipsychotics, clozapine works by blocking dopamine D2 receptors more selectively while also acting on serotonin 5-HT2A receptors, leading to improved symptom control with a lower risk of extrapyramidal side effects such as tremors, rigidity, and involuntary movements. Additionally, clozapine has been shown to reduce suicidal tendencies in patients with schizophrenia, making it a lifesaving option for those at high risk of self-harm.

Despite its effectiveness, clozapine requires strict monitoring due to potential serious side effects, including agranulocytosis, a rare but dangerous condition where white blood cell counts drop significantly, increasing the risk of severe infections. Regular blood tests are mandatory to monitor white blood cell levels and ensure patient safety. Other common side effects include weight gain, sedation, dizziness, and metabolic disturbances, such as an increased risk of diabetes and high cholesterol. Due to these risks, clozapine is typically prescribed only when other antipsychotics have failed and is closely supervised by healthcare professionals. However, for individuals who do not respond to standard treatments, clozapine remains one of the most effective options for achieving long-term stability and improving overall quality of life.

• Certificate of Analysis (COA)
• Method of Analysis (MOA)
• Route of Synthesis (ROS)
• Good Manufacturing Practice (GMP) Compliance
• International Organization for Standardization (ISO) Certification
• Open Drug Master File (OP-DMF)
• Stability Data & Reports

Pharmacopoeia	IP / USP / EP / BP
CAS No.	5786-21-0
Formula	C18H19CLN4
Molecular Weight	326.8

Clozapine is an atypical antipsychotic medication primarily prescribed for treatment-resistant schizophrenia, a condition where symptoms persist despite the use of other antipsychotic drugs. It is particularly effective in reducing hallucinations, delusions, and disorganized thinking in patients who have not responded to conventional treatments. Unlike typical antipsychotics, clozapine works by blocking dopamine D2 receptors more selectively while also acting on serotonin 5-HT2A receptors, leading to improved symptom control with a lower risk of extrapyramidal side effects such as tremors, rigidity, and involuntary movements. Additionally, clozapine has been shown to reduce suicidal tendencies in patients with schizophrenia, making it a lifesaving option for those at high risk of self-harm.

Despite its effectiveness, clozapine requires strict monitoring due to potential serious side effects, including agranulocytosis, a rare but dangerous condition where white blood cell counts drop significantly, increasing the risk of severe infections. Regular blood tests are mandatory to monitor white blood cell levels and ensure patient safety. Other common side effects include weight gain, sedation, dizziness, and metabolic disturbances, such as an increased risk of diabetes and high cholesterol. Due to these risks, clozapine is typically prescribed only when other antipsychotics have failed and is closely supervised by healthcare professionals. However, for individuals who do not respond to standard treatments, clozapine remains one of the most effective options for achieving long-term stability and improving overall quality of life.

• Certificate of Analysis (COA)
• Method of Analysis (MOA)
• Route of Synthesis (ROS)
• Good Manufacturing Practice (GMP) Compliance
• International Organization for Standardization (ISO) Certification
• Open Drug Master File (OP-DMF)
• Stability Data & Reports

Pharmacopoeia	IP / USP / EP / BP
CAS No.	5786-21-0
Formula	C18H19CLN4
Molecular Weight	326.8